Which medical condition can lead to paralysis of all limbs?

The condition that directly leads to paralysis of all limbs is quadriplegia. Quadriplegia refers to a loss of function and sensation in all four limbs (both arms and legs) due to damage to the spinal cord, usually at a cervical level. This complete paralysis occurs when the nerve signals between the brain and the limbs are interrupted, preventing movement and sensation.

While stroke and conditions like multiple sclerosis can lead to varying degrees of paralysis or weakness in limbs, they do not specifically denote the complete paralysis of all four limbs as quadriplegia does. Neuropathy involves nerve damage that can cause weakness, numbness, or pain in the extremities, but it does not imply total paralysis of all limbs either. Therefore, quadriplegia is the most accurate choice directly associated with the total paralysis of all limbs.