What is the main characteristic of lymphedema?

The main characteristic of lymphedema is swelling of tissues. This condition is primarily caused by an accumulation of lymphatic fluid due to an obstruction or dysfunction in the lymphatic system. When the lymphatic system is unable to adequately manage the drainage of lymph fluid from tissues, it leads to this noticeable swelling, which can often occur in the limbs, but may also affect other areas of the body. The swelling can be persistent and may vary in severity depending on the underlying causes or the effectiveness of any treatments.

While inflammation, bacterial infection, and neoplastic disease can be associated with various medical conditions, they do not define lymphedema itself. Inflammation may accompany lymphedema but is not a primary characteristic, and neither bacterial infection nor neoplastic disease are direct attributes of lymphedema as a condition. Hence, swelling of tissues is the most accurate characteristic that defines lymphedema.